Cerebrospinal fluid–based kinetic biomarkers of axonal transport in monitoring neurodegeneration

Progress in neurodegenerative disease research is hampered by the lack of biomarkers of neuronal dysfunction. We here identified a class of cerebrospinal fluid–based (CSF-based) kinetic biomarkers that reflect altered neuronal transport of protein cargo, a common feature of neurodegeneration. After...

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Detalhes bibliográficos
Main Authors: Fanara, Patrizia, Wong, Po-Yin A., Husted, Kristofor H., Liu, Shanshan, Liu, Victoria M., Kohlstaedt, Lori A., Riiff, Timothy, Protasio, Joan C., Boban, Drina, Killion, Salena, Killian, Maudi, Epling, Lorrie, Sinclair, Elisabeth, Peterson, Julia, Price, Richard W., Cabin, Deborah E., Nussbaum, Robert L., Brühmann, Jörg, Brandt, Roland, Christine, Chadwick W., Aminoff, Michael J., Hellerstein, Marc K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Technical Advance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428100/
https://ncbi.nlm.nih.gov/pubmed/22922254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64575
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