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TLR-Mediated B Cell Defects and IFN-α in Common Variable Immunodeficiency
Common variable immune deficiency (CVID) B cells have impaired responses to TLR7 and TLR9 agonists including poor cell proliferation, loss of cytokine production, and failure to produce IgG or IgA. We show that TLR7- or 9-activated B cells from CVID subjects with >0.5% peripheral isotype-switched...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3428015/ https://ncbi.nlm.nih.gov/pubmed/22048980 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10875-011-9602-y |
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