Detection of Expression Quantitative Trait Loci in Complex Mouse Crosses: Impact and Alleviation of Data Quality and Complex Population Substructure

Complex Mus musculus crosses, e.g., heterogeneous stock (HS), provide increased resolution for quantitative trait loci detection. However, increased genetic complexity challenges detection methods, with discordant results due to low data quality or complex genetic architecture. We quantified the imp...

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Main Authors: Iancu, Ovidiu D., Darakjian, Priscila, Kawane, Sunita, Bottomly, Daniel, Hitzemann, Robert, McWeeney, Shannon
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Research Foundation 2012
Assuntos:
Genetics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427913/
https://ncbi.nlm.nih.gov/pubmed/22969789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2012.00157
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