Detection of Expression Quantitative Trait Loci in Complex Mouse Crosses: Impact and Alleviation of Data Quality and Complex Population Substructure

Complex Mus musculus crosses, e.g., heterogeneous stock (HS), provide increased resolution for quantitative trait loci detection. However, increased genetic complexity challenges detection methods, with discordant results due to low data quality or complex genetic architecture. We quantified the imp...

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Autors principals: Iancu, Ovidiu D., Darakjian, Priscila, Kawane, Sunita, Bottomly, Daniel, Hitzemann, Robert, McWeeney, Shannon
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Research Foundation 2012
Matèries:
Genetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427913/
https://ncbi.nlm.nih.gov/pubmed/22969789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2012.00157
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