Upregulation of miR-24 is associated with a decreased DNA damage response upon etoposide treatment in highly differentiated CD8(+) T cells sensitizing them to apoptotic cell death

The life-long homeostasis of memory CD8(+) T cells as well as persistent viral infections have been shown to facilitate the accumulation of highly differentiated CD8(+)CD28(−) T cells, a phenomenon that has been associated with an impaired immune function in humans. However, the molecular mechanisms...

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Dettagli Bibliografici
Autori principali: Brunner, Stefan, Herndler-Brandstetter, Dietmar, Arnold, Christoph R, Wiegers, Gerrit Jan, Villunger, Andreas, Hackl, Matthias, Grillari, Johannes, Moreno-Villanueva, María, Bürkle, Alexander, Grubeck-Loebenstein, Beatrix
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2012
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427896/
https://ncbi.nlm.nih.gov/pubmed/22435726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2012.00819.x
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