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Trifunctional Agents as a Design Strategy for Tailoring Ligand Properties: Irreversible Inhibitors of A(1) Adenosine Receptors

The 1,3-phenylene diisothiocyanate conjugate of XAC (8-[4-[[[[(2-aminoethyl)amino]carbonyl]methyl]-oxy]phenyl]-l,3-dipropylxanthine, a potent A(1) selective adenosine antagonist) has been characterized as an irreversible inhibitor of A(1) adenosine receptors. To further extend this work, a series of...

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Bibliografiske detaljer
Main Authors: Boring, Daniel L., Ji, Xiao-Duo, Zimmet, Jeff, Taylor, Kirk E., Stiles, Gary L., Jacobson, Kenneth A.
Format: Artigo
Sprog:Inglês
Udgivet: 1991
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427756/
https://ncbi.nlm.nih.gov/pubmed/1868116
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