Tubulin-Destabilizing Agent BPR0L075 Induces Vascular-Disruption in Human Breast Cancer Mammary Fat Pad Xenografts

BPR0L075, 6-methoxy-3-(3′,4′,5′-trimethoxy-benzoyl)-1H-indole, is a tubulin-binding agent that inhibits tubulin polymerization by binding to the colchicine-binding site. BPR0L075 has shown antimitotic and antiangiogenic activity in vitro. The current study evaluated the vascular-disrupting activity...

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Hlavní autoři: Liu, Li, Beck, Haley, Wang, Xiaolei, Hsieh, Hsing-Pang, Mason, Ralph P., Liu, Xinli
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427339/
https://ncbi.nlm.nih.gov/pubmed/22937031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043314
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