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Crosstalk between the UPR and autophagy pathway contributes to handling cellular stress in neurodegenerative disease
Huntington disease (HD) is caused by an extended polyglutamine [poly(Q)] stretch in the Huntingtin (HTT) protein, and is associated with the accumulation of intracellular protein aggregates, onset of progressive chorea, psychiatric symptoms and dementia. Although the mechanism underlying the patholo...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3427262/ https://ncbi.nlm.nih.gov/pubmed/22617512 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.20139 |
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