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The Mre11 Nuclease Is Critical for the Sensitivity of Cells to Chk1 Inhibition

The Chk1 kinase is required for the arrest of cell cycle progression when DNA is damaged, and for stabilizing stalled replication forks. As a consequence, many Chk1 inhibitors have been developed and tested for their potential to enhance DNA damage-induced tumor cell killing. However, inhibition of...

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Detaylı Bibliyografya
Asıl Yazarlar: Thompson, Ruth, Montano, Ryan, Eastman, Alan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2012
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427249/
https://ncbi.nlm.nih.gov/pubmed/22937147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044021
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