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FunSAV: Predicting the Functional Effect of Single Amino Acid Variants Using a Two-Stage Random Forest Model

Single amino acid variants (SAVs) are the most abundant form of known genetic variations associated with human disease. Successful prediction of the functional impact of SAVs from sequences can thus lead to an improved understanding of the underlying mechanisms of why a SAV may be associated with ce...

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Autores principales: Wang, Mingjun, Zhao, Xing-Ming, Takemoto, Kazuhiro, Xu, Haisong, Li, Yuan, Akutsu, Tatsuya, Song, Jiangning
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427247/
https://ncbi.nlm.nih.gov/pubmed/22937107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043847
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