Structural and functional analysis of phosphorylation-specific binders of the kinase ERK from designed ankyrin repeat protein libraries

We have selected designed ankyrin repeat proteins (DARPins) from a synthetic library by using ribosome display that selectively bind to the mitogen-activated protein kinase ERK2 (extracellular signal-regulated kinase 2) in either its nonphosphorylated (inactive) or doubly phosphorylated (active) for...

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Detalhes bibliográficos
Main Authors: Kummer, Lutz, Parizek, Petra, Rube, Peter, Millgramm, Bastian, Prinz, Anke, Mittl, Peer R. E., Kaufholz, Melanie, Zimmermann, Bastian, Herberg, Friedrich W., Plückthun, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427131/
https://ncbi.nlm.nih.gov/pubmed/22843676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205399109
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