Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids

The rs1061170T/C variant encoding the Y402H change in complement factor H (CFH) has been identified by genome-wide association studies as being significantly associated with age-related macular degeneration (AMD). However, the precise mechanism by which this CFH variant impacts the risk of AMD remai...

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Bibliografische gegevens
Hoofdauteurs: Shaw, Peter X., Zhang, Li, Zhang, Ming, Du, Hongjun, Zhao, Ling, Lee, Clara, Grob, Seanna, Lim, Siok Lam, Hughes, Guy, Lee, Janet, Bedell, Matthew, Nelson, Mark H., Lu, Fang, Krupa, Martin, Luo, Jing, Ouyang, Hong, Tu, Zhidan, Su, Zhiguang, Zhu, Jin, Wei, Xinran, Feng, Zishan, Duan, Yaou, Yang, Zhenglin, Ferreyra, Henry, Bartsch, Dirk-Uwe, Kozak, Igor, Zhang, Liangfang, Lin, Feng, Sun, Hui, Feng, Hong, Zhang, Kang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2012
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427125/
https://ncbi.nlm.nih.gov/pubmed/22875704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1121309109
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