Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids

The rs1061170T/C variant encoding the Y402H change in complement factor H (CFH) has been identified by genome-wide association studies as being significantly associated with age-related macular degeneration (AMD). However, the precise mechanism by which this CFH variant impacts the risk of AMD remai...

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Detalhes bibliográficos
Main Authors: Shaw, Peter X., Zhang, Li, Zhang, Ming, Du, Hongjun, Zhao, Ling, Lee, Clara, Grob, Seanna, Lim, Siok Lam, Hughes, Guy, Lee, Janet, Bedell, Matthew, Nelson, Mark H., Lu, Fang, Krupa, Martin, Luo, Jing, Ouyang, Hong, Tu, Zhidan, Su, Zhiguang, Zhu, Jin, Wei, Xinran, Feng, Zishan, Duan, Yaou, Yang, Zhenglin, Ferreyra, Henry, Bartsch, Dirk-Uwe, Kozak, Igor, Zhang, Liangfang, Lin, Feng, Sun, Hui, Feng, Hong, Zhang, Kang
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427125/
https://ncbi.nlm.nih.gov/pubmed/22875704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1121309109
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