Oncogenic Myc translocations are independent of chromosomal location and orientation of the immunoglobulin heavy chain locus

Many tumors are characterized by recurrent translocations between a tissue-specific gene and a proto-oncogene. The juxtaposition of the Ig heavy chain gene and Myc in Burkitt’s lymphoma and in murine plasmacytoma is a classic example. Regulatory elements within the heavy chain constant region locus...

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Detalhes bibliográficos
Main Authors: Spehalski, Elizabeth, Kovalchuk, Alexander L., Collins, John T., Liang, Genqing, Dubois, Wendy, Morse, Herbert. C., Ferguson, David O., Casellas, Rafael, Dunnick, Wesley A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427096/
https://ncbi.nlm.nih.gov/pubmed/22869734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202882109
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