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Identification of an N-terminal inhibitory extension as the primary mechanosensory regulator of twitchin kinase

Titin-like kinases are an important class of cytoskeletal kinases that intervene in the response of muscle to mechanical stimulation, being central to myofibril homeostasis and development. These kinases exist in autoinhibited states and, allegedly, become activated during muscle activity by the ela...

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Main Authors: von Castelmur, Eleonore, Strümpfer, Johan, Franke, Barbara, Bogomolovas, Julijus, Barbieri, Sonia, Qadota, Hiroshi, Konarev, Petr V., Svergun, Dmitri I., Labeit, Siegfried, Benian, Guy M., Schulten, Klaus, Mayans, Olga
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427058/
https://ncbi.nlm.nih.gov/pubmed/22869697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1200697109
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