Common variants at 11p13 are associated with susceptibility to tuberculosis

After imputation of data of the 1000 Genomes Project into a genome-wide data set of Ghanaian tuberculosis cases and controls, we identified a resistance locus on chromosome 11p13, downstream of the Wilms' tumour 1 gene. The strongest signal was obtained at SNP rs2057178 (P = 2.63 × 10(−9)). Rep...

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Main Authors: Thye, Thorsten, Owusu-Dabo, Ellis, Vannberg, Fredrik O., van Crevel, Reinout, Curtis, James, Sahiratmadja, Edhyana, Balabanova, Yanina, Ehmen, Christa, Muntau, Birgit, Ruge, Gerd, Sievertsen, Jürgen, Gyapong, John, Nikolayevskyy, Vladyslav, Hill, Philip C., Sirugo, Giorgio, Drobniewski, Francis, van de Vosse, Esther, Newport, Melanie, Alisjahbana, Bachti, Nejentsev, Sergey, Ottenhoff, Tom H.M., Hill, Adrian V.S., Horstmann, Rolf D., Meyer, Christian G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427019/
https://ncbi.nlm.nih.gov/pubmed/22306650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.1080
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