TGF-β is responsible for NK cell immaturity during ontogeny and increased susceptibility to infection during mouse infancy

A major gap in our understanding of infant immunity is why natural killer (NK) cellresponses are deficient, making infants more prone to viral infection. Here we demonstrate that transforming growth factor-β (TGF-β) was responsible for NK cell immaturity during infancy. Higher numbers of fully matur...

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Detalhes bibliográficos
Main Authors: Marcoe, Jeffrey P., Lim, James R., Schaubert, Keri L., Fodil-Cornu, Nassima, Matka, Marsel, McCubbrey, Alexandra L., Farr, Alexander R., Vidal, Silvia M., Laouar, Yasmina
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3426626/
https://ncbi.nlm.nih.gov/pubmed/22863752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2388
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