Proposed megakaryocytic regulon of p53: the genes engaged to control cell cycle and apoptosis during megakaryocytic differentiation

During endomitosis, megakaryocytes undergo several rounds of DNA synthesis without division leading to polyploidization. In primary megakaryocytes and in the megakaryocytic cell line CHRF, loss or knock-down of p53 enhances cell cycling and inhibits apoptosis, leading to increased polyploidization....

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Main Authors: Apostolidis, Pani A., Lindsey, Stephan, Miller, William M., Papoutsakis, Eleftherios T.
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2012
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3426429/
https://ncbi.nlm.nih.gov/pubmed/22548738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00028.2012
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