Nonsynonymous variants in mt-Nd2, mt-Nd4, and mt-Nd5 are linked to effects on oxidative phosphorylation and insulin sensitivity in rat conplastic strains

Common inbred strains of the laboratory rat can be divided into four different mitochondrial DNA haplotype groups represented by the SHR, BN, LEW, and F344 strains. In the current study, we investigated the metabolic and hemodynamic effects of the SHR vs. LEW mitochondrial genomes by comparing the S...

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Autori principali: Houštěk, Josef, Hejzlarová, Kateřina, Vrbacký, Marek, Drahota, Zdeněk, Landa, Vladimír, Zídek, Václav, Mlejnek, Petr, Šimáková, Miroslava, Šilhavý, Jan, Mikšík, Ivan, Kazdová, Ludmila, Oliyarnyk, Olena, Kurtz, Theodore, Pravenec, Michal
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3426424/
https://ncbi.nlm.nih.gov/pubmed/22414913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00156.2011
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