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Single nucleotide polymorphisms of the adult intestinal stem cell marker Lgr5 in primary and metastatic colorectal cancer

Morphological and clinical heterogeneity of advanced colorectal cancer is probably caused by genetic variability in putative cancer stem cell genes, including Lgr5. Here, we investigated 23 variants of the Lgr5 gene in normal tissue, primary tumors, lymph node metastases and distant metastases of st...

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Autori principali: Kleist, Britta, Xu, Li, Kersten, Christian, Seel, Violetta, Li, Guojun, Poetsch, Micaela
Natura: Artigo
Lingua:Inglês
Pubblicazione: e-Century Publishing Corporation 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3426388/
https://ncbi.nlm.nih.gov/pubmed/22937206
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