Genomic amplification and a role in drug-resistance for the KDM5A histone demethylase in breast cancer

Lysine-specific demethylase 5A (KDM5A), an enzyme that removes activating H3K4 di- and trimethylation marks, plays critical roles in controlling transcription and chromatin architecture, yet its biological functions largely remain uncharacterized, particularly in the context of human cancer. In the...

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Autors principals: Hou, Jinling, Wu, Jack, Dombkowski, Alan, Zhang, Kezhong, Holowatyj, Andreana, Boerner, Julie L, Yang, Zeng-Quan
Format: Artigo
Idioma:Inglês
Publicat: e-Century Publishing Corporation 2012
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3426386/
https://ncbi.nlm.nih.gov/pubmed/22937203
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