The potential for respiratory droplet transmissible A/H5N1 influenza virus to evolve in a mammalian host

Avian A/H5N1 influenza viruses pose a pandemic threat. As few as five amino acid substitutions, or four with reassortment, might be sufficient for mammal-to-mammal transmission by respiratory droplets. From surveillance data we find that two of these substitutions are common in A/H5N1 viruses and th...

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Main Authors: Russell, Colin A., Fonville, Judith M., Brown, André E. X., Burke, David F., Smith, David L., James, Sarah L., Herfst, Sander, van Boheemen, Sander, Linster, Martin, Schrauwen, Eefje J., Katzelnick, Leah, Mosterín, Ana, Kuiken, Thijs, Maher, Eileen, Neumann, Gabriele, Osterhaus, Albert D. M. E., Kawaoka, Yoshihiro, Fouchier, Ron A. M., Smith, Derek J.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3426314/
https://ncbi.nlm.nih.gov/pubmed/22723414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1222526
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