Cyclic Peptides Arising by Evolutionary Parallelism via Asparaginyl-Endopeptidase–Mediated Biosynthesis([C])([W])

The cyclic miniprotein Momordica cochinchinensis Trypsin Inhibitor II (MCoTI-II) (34 amino acids) is a potent trypsin inhibitor (TI) and a favored scaffold for drug design. We have cloned the corresponding genes and determined that each precursor protein contains a tandem series of cyclic TIs termin...

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Main Authors: Mylne, Joshua S., Chan, Lai Yue, Chanson, Aurelie H., Daly, Norelle L., Schaefer, Hanno, Bailey, Timothy L., Nguyencong, Philip, Cascales, Laura, Craik, David J.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Plant Biologists 2012
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3426113/
https://ncbi.nlm.nih.gov/pubmed/22822203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1105/tpc.112.099085
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