Increased MET and HGF gene copy numbers are associated with trastuzumab failure in HER2-positive metastatic breast cancer

BACKGROUND: To investigate whether copy number gain of MET or hepatocyte growth factor (HGF) affect trastuzumab sensitivity in HER2-positive metastatic breast cancer (MBC). METHODS: We analysed 130 HER2-positive MBC treated with trastuzumab-based therapy. MET and HGF gene copy numbers (GCN) were ass...

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Detalhes bibliográficos
Main Authors: Minuti, G, Cappuzzo, F, Duchnowska, R, Jassem, J, Fabi, A, O’Brien, T, Mendoza, A D, Landi, L, Biernat, W, Czartoryska-Arłukowicz, B, Jankowski, T, Zuziak, D, Zok, J, Szostakiewicz, B, Foszczyńska-Kłoda, M, Tempińska-Szałach, A, Rossi, E, Varella-Garcia, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3425981/
https://ncbi.nlm.nih.gov/pubmed/22850551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.335
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