Ex Vivo SIV-Specific CD8 T Cell Responses in Heterozygous Animals Are Primarily Directed against Peptides Presented by a Single MHC Haplotype

The presence of certain MHC class I alleles is correlated with remarkable control of HIV and SIV, indicating that specific CD8 T cell responses can effectively reduce viral replication. It remains unclear whether epitopic breadth is an important feature of this control. Previous studies have suggest...

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Hlavní autoři: Greene, Justin M., Chin, Emily N., Budde, Melisa L., Lhost, Jennifer J., Hines, Paul J., Burwitz, Benjamin J., Broman, Karl W., Nelson, Jennifer E., Friedrich, Thomas C., O’Connor, David H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3425510/
https://ncbi.nlm.nih.gov/pubmed/22928016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043690
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