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Substrate specificity of 6-O-endosulfatase (Sulf-2) and its implications in synthesizing anticoagulant heparan sulfate

Heparan sulfate (HS) 6-O-endosulfatase (Sulf) catalyzes the hydrolysis of 6-O-sulfo groups from HS polysaccharides. The resultant HS has reduced sulfation levels and displays altered biological activities. The Sulfs have been associated with several cancers and developmental problems and could funct...

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Sonraí Bibleagrafaíochta
Main Authors: Pempe, Elizabeth H, Burch, Tanya C, Law, Courtney J, Liu, Jian
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3425325/
https://ncbi.nlm.nih.gov/pubmed/22692045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/glycob/cws092
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