Improved bioavailability of inhibitors of Trypanosoma cruzi trans-sialidase: PEGylation of lactose analogs with multiarm polyethyleneglycol

The trans-sialidase of Trypanosoma cruzi (TcTS) catalyzes the transfer of sialic acid from host glycoconjugates to terminal β-galactopyranosides in the mucins of the parasite. During infection, the enzyme is actively shed by the parasite to the bloodstream inducing hematological alterations. Lactito...

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Autors principals: Giorgi, M. Eugenia, Ratier, Laura, Agusti, Rosalía, Frasch, Alberto C.C., de Lederkremer, Rosa M.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2012
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3425324/
https://ncbi.nlm.nih.gov/pubmed/22653661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/glycob/cws091
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