Suppression of GM-CSF expression in murine and human T cells by IL-27

GM-CSF is a potent pro-inflammatory cytokine that plays a pathogenic role in the CNS inflammatory disease, EAE. As IL-27 ameliorates EAE, we hypothesised that IL-27 suppresses GM-CSF expression by T cells. We found that IL-27 suppressed GM-CSF expression in CD4(+) and CD8(+) T cells in splenocyte an...

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Autors principals: Young, Andrew, Linehan, Eimear, Hams, Emily, O’Hara Hall, Aisling C., McClurg, Angela, Johnston, James A., Hunter, Christopher A., Fallon, Padraic G., Fitzgerald, Denise C.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424384/
https://ncbi.nlm.nih.gov/pubmed/22837488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200131
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