The Crystal Structures of the Tryparedoxin-Tryparedoxin Peroxidase Couple Unveil the Structural Determinants of Leishmania Detoxification Pathway

Leishmaniasis is a neglected disease caused by Leishmania, an intracellular protozoan parasite which possesses a unique thiol metabolism based on trypanothione. Trypanothione is used as a source of electrons by the tryparedoxin/tryparedoxin peroxidase system (TXN/TXNPx) to reduce the hydroperoxides...

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Hlavní autoři: Fiorillo, Annarita, Colotti, Gianni, Boffi, Alberto, Baiocco, Paola, Ilari, Andrea
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424247/
https://ncbi.nlm.nih.gov/pubmed/22928053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0001781
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