Mutations in Escherichia coli aceE and ribB Genes Allow Survival of Strains Defective in the First Step of the Isoprenoid Biosynthesis Pathway

A functional 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway is required for isoprenoid biosynthesis and hence survival in Escherichia coli and most other bacteria. In the first two steps of the pathway, MEP is produced from the central metabolic intermediates pyruvate and glyceraldehyde 3-phospha...

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Main Authors: Perez-Gil, Jordi, Uros, Eva Maria, Sauret-Güeto, Susanna, Lois, L. Maria, Kirby, James, Nishimoto, Minobu, Baidoo, Edward E. K., Keasling, Jay D., Boronat, Albert, Rodriguez-Concepcion, Manuel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424233/
https://ncbi.nlm.nih.gov/pubmed/22928031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043775
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