Mutations in Escherichia coli aceE and ribB Genes Allow Survival of Strains Defective in the First Step of the Isoprenoid Biosynthesis Pathway

A functional 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway is required for isoprenoid biosynthesis and hence survival in Escherichia coli and most other bacteria. In the first two steps of the pathway, MEP is produced from the central metabolic intermediates pyruvate and glyceraldehyde 3-phospha...

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Bibliografiska uppgifter
Huvudupphovsmän: Perez-Gil, Jordi, Uros, Eva Maria, Sauret-Güeto, Susanna, Lois, L. Maria, Kirby, James, Nishimoto, Minobu, Baidoo, Edward E. K., Keasling, Jay D., Boronat, Albert, Rodriguez-Concepcion, Manuel
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2012
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424233/
https://ncbi.nlm.nih.gov/pubmed/22928031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043775
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