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Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes

A major pathway for B cell acquisition of lymph-borne particulate antigens relies on antigen capture by subcapsular sinus macrophages of the lymph node. Here we tested whether this mechanism is also important for humoral immunity to inactivated influenza virus. By multiple approaches, including mult...

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Detalhes bibliográficos
Main Authors: Gonzalez, Santiago F, Lukacs-Kornek, Veronika, Kuligowski, Michael P, Pitcher, Lisa A, Degn, Søren E, Kim, Young-A, Cloninger, Mary J, Martinez-Pomares, Luisa, Gordon, Siamon, Turley, Shannon J, Carroll, Michael C
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424101/
https://ncbi.nlm.nih.gov/pubmed/20305659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1856
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