Pten deletion causes mTorc1-dependent ectopic neuroblast differentiation without causing uniform migration defects

Neuronal precursors, generated throughout life in the subventricular zone, migrate through the rostral migratory stream to the olfactory bulb where they differentiate into interneurons. We found that the PI3K-Akt-mTorc1 pathway is selectively inactivated in migrating neuroblasts in the subventricula...

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Detalhes bibliográficos
Principais autores: Zhu, Guo, Chow, Lionel M. L., Bayazitov, Ildar T., Tong, Yiai, Gilbertson, Richard J., Zakharenko, Stanislav S., Solecki, David J., Baker, Suzanne J.
Formato: Artigo
Idioma:Inglês
Publicado em: Company of Biologists 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424045/
https://ncbi.nlm.nih.gov/pubmed/22874917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.083154
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