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Chronic inflammation and aging: DNA damage tips the balance

The aged immune system, typically hyporesponsive to infection and vaccination, can be hyperresponsive in the context of inflammatory pathology. Here we review current work examining the mechanisms behind the amplified inflammatory profile of aged adaptive immunity, and the reciprocal relationship be...

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Detalhes bibliográficos
Main Authors: Cavanagh, Mary M., Weyand, Cornelia M., Goronzy, Jörg J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423478/
https://ncbi.nlm.nih.gov/pubmed/22565047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coi.2012.04.003
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