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Co-Occurrence of TDP-43 Mislocalization with Reduced Activity of an RNA Editing Enzyme, ADAR2, in Aged Mouse Motor Neurons

TDP-43 pathology in spinal motor neurons is a neuropathological hallmark of sporadic amyotrophic lateral sclerosis (ALS) and has recently been shown to be closely associated with the downregulation of an RNA editing enzyme called adenosine deaminase acting on RNA 2 (ADAR2) in the motor neurons of sp...

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Hlavní autoři: Hideyama, Takuto, Teramoto, Sayaka, Hachiga, Kosuke, Yamashita, Takenari, Kwak, Shin
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423340/
https://ncbi.nlm.nih.gov/pubmed/22916266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043469
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