The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine-induced dopamine elevations in the nucleus accumbens shell in rats

BACKGROUND AND PURPOSE: The fatty acid amide hydrolase inhibitor URB597 can reverse the abuse-related behavioural and neurochemical effects of nicotine in rats. Fatty acid amide hydrolase inhibitors block the degradation (and thereby magnify and prolong the actions) of the endocannabinoid anandamide...

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Main Authors: Scherma, Maria, Justinová, Zuzana, Zanettini, Claudio, Panlilio, Leigh V, Mascia, Paola, Fadda, Paola, Fratta, Walter, Makriyannis, Alexandros, Vadivel, Subramanian K, Gamaleddin, Islam, Le Foll, Bernard, Goldberg, Steven R
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2012
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Themed Section: Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423245/
https://ncbi.nlm.nih.gov/pubmed/21557729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01467.x
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