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Mitofusins and the mitochondrial permeability transition: the potential downside of mitochondrial fusion

Mitofusins (Mfn-1 and Mfn-2) are transmembrane proteins that bind and hydrolyze guanosine 5′-triphosphate to bring about the merging of adjacent mitochondrial membranes. This event is necessary for mitochondrial fusion, a biological process that is critical for organelle function. The broad effects...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Papanicolaou, Kyriakos N., Phillippo, Matthew M., Walsh, Kenneth
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423162/
https://ncbi.nlm.nih.gov/pubmed/22636681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00185.2012
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