Statin therapy lowers muscle sympathetic nerve activity and oxidative stress in patients with heart failure

Despite standard drug therapy, sympathetic nerve activity (SNA) remains high in heart failure (HF) patients making the sympathetic nervous system a primary drug target in the treatment of HF. Studies in rabbits with pacing-induced HF have demonstrated that statins reduce resting SNA, in part, due to...

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Bibliographic Details
Main Authors: Deo, Shekhar H., Fisher, James P., Vianna, Lauro C., Kim, Areum, Chockalingam, Anand, Zimmerman, Matthew C., Zucker, Irving H., Fadel, Paul J.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2012
Subjects:
Integrative Cardiovascular Physiology and Pathophysiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423160/
https://ncbi.nlm.nih.gov/pubmed/22661508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00289.2012
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