A novel anti-EMMPRIN function-blocking antibody reduces T cell proliferation and neurotoxicity: relevance to multiple sclerosis

BACKGROUND: Extracellular matrix metalloproteinase inducer (EMMPRIN; CD147, basigin) is an inducer of the expression of several matrix metalloproteinases (MMPs). We reported previously that blocking EMMPRIN activity reduced neuroinflammation and severity of disease in an animal model of multiple scl...

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Bibliografiske detaljer
Main Authors: Agrawal, Smriti M, Silva, Claudia, Wang, Janet, Tong, Jade Pui-Wai, Yong, V Wee
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423076/
https://ncbi.nlm.nih.gov/pubmed/22480370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-64
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