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Gα(q/11)-mediated intracellular calcium responses to retrograde flow in endothelial cells

Disturbed flow patterns, including reversal in flow direction, are key factors in the development of dysfunctional endothelial cells (ECs) and atherosclerotic lesions. An almost immediate response of ECs to fluid shear stress is the increase in cytosolic calcium concentration ([Ca(2+)](i)). Whether...

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Main Authors: Melchior, Benoît, Frangos, John A.
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422983/
https://ncbi.nlm.nih.gov/pubmed/22700794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00117.2012
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