Bone progenitor dysfunction induces myelodysplasia and secondary leukemia

Mesenchymal cell populations contribute to microenvironments regulating stem cells and the growth of malignant cells. Osteolineage cells participate in the hematopoietic stem cell niche. Here, we report that deletion of the miRNA processing endonuclease Dicer1 selectively in mesenchymal osteoprogeni...

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Detalhes bibliográficos
Main Authors: Raaijmakers, Marc H.G.P., Mukherjee, Siddhartha, Guo, Shangqin, Zhang, Siyi, Kobayashi, Tatsuya, Schoonmaker, Jesse A., Ebert, Benjamin L., Al-Shahrour, Fatima, Hasserjian, Robert P., Scadden, Edward O., Aung, Zinmar, Matza, Marc, Merkenschlager, Matthias, Lin, Charles, Rommens, Johanna M., Scadden, David. T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422863/
https://ncbi.nlm.nih.gov/pubmed/20305640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08851
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