Structural aspects of activation pathways of aspartic protease zymogens and viral 3C protease precursors

The three-dimensional structures of the inactive protein precursors (zymogens) of the serine, cysteine, aspartic, and metalloprotease classes of proteolytic enzymes are known. Comparisons of these structures with those of the mature, active proteases reveal that, in general, the preformed, active co...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Khan, Amir R., Khazanovich-Bernstein, Nina, Bergmann, Ernst M., James, Michael N. G.
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1999
Sujets:	Colloquium Paper
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC34228/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10500110/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.20.10968
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