Inactivation of the putative suppressor gene DOK1 by promoter hypermethylation in primary human cancers

The DOK1 gene is a putative tumour suppressor gene located on the human chromosome 2p13 which is frequently rearranged in leukemia and other human tumours. We previously reported that the DOK1 gene can be mutated and its expression down-regulated in human malignancies. However, the mechanism underly...

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Autori principali: Saulnier, Amandine, Vaissière, Thomas, Yue, Jiping, Siouda, Maha, Malfroy, Marine, Accardi, Rosita, Creveaux, Marion, Sebastian, Sinto, Shahzad, Naveed, Gheit, Tarik, Hussain, Ishraq, Torrente, Mariela, Maffini, Fausto Antonio, Calabrese, Luca, Chiesa, Fausto, Cuenin, Cyrille, Shukla, Ruchi, Fathallah, Ikbal, Matos, Elena, Daudt, Alexander, Koifman, Sergio, Wünsch-Filho, Victor, Menezes, Ana M. B., Curado, Maria-Paula, Zaridze, David, Boffetta, Paolo, Brennan, Paul, Tommasino, Massimo, Herceg, Zdenko, Sylla, Bakary S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422753/
https://ncbi.nlm.nih.gov/pubmed/21796618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.26299
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