dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8

Toll-like receptor 3 (TLR3) is a pattern-recognition receptor known to initiate an innate immune response when stimulated by double-stranded RNA (dsRNA). Components of TLR3 signaling, including TIR domain-containing adapter inducing IFN-α (TRIF), have been demonstrated to contribute to dsRNA-induced...

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Autors principals: Estornes, Y, Toscano, F, Virard, F, Jacquemin, G, Pierrot, A, Vanbervliet, B, Bonnin, M, Lalaoui, N, Mercier-Gouy, P, Pachéco, Y, Salaun, B, Renno, T, Micheau, O, Lebecque, S
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422471/
https://ncbi.nlm.nih.gov/pubmed/22421964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.22
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