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PAX5 activates the transcription of the human telomerase reverse transcriptase gene in B cells

Telomerase is an RNA-dependent DNA polymerase that synthesizes telomeric DNA. Its activity is not detectable in most somatic cells but it is reactivated during tumorigenesis. In most cancers, the combination of hTERT hypermethylation and hypomethylation of a short promoter region is permissive for l...

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Détails bibliographiques
Auteurs principaux: Bougel, Stéphanie, Renaud, Stéphanie, Braunschweig, Richard, Loukinov, Dmitri, Morse, Herbert C, Bosman, Fred T., Lobanenkov, Victor, Benhattar, Jean
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422366/
https://ncbi.nlm.nih.gov/pubmed/19806612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.2620
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