Simultaneous Detection of Ca(2+) and Diacylglycerol Signaling in Living Cells

Phospholipase C produces two second messengers - diacylglycerol (DAG), which remains in the membrane, and inositol triphosphate (IP(3)), which triggers the release of calcium ions (Ca(2+)) from intracellular stores. Genetically encoded sensors based on a single circularly permuted fluorescent protei...

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Bibliographic Details
Main Authors: Tewson, Paul, Westenberg, Mara, Zhao, Yongxin, Campbell, Robert E., Quinn, Anne Marie, Hughes, Thomas E.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422227/
https://ncbi.nlm.nih.gov/pubmed/22912738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042791
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