Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency

AIMS: The shRNA-mediated loss of expression of the desmosomal protein plakophilin-2 leads to sodium current (I(Na)) dysfunction. Whether pkp2 gene haploinsufficiency leads to I(Na) deficit in vivo remains undefined. Mutations in pkp2 are detected in arrhythmogenic right ventricular cardiomyopathy (A...

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Autors principals: Cerrone, Marina, Noorman, Maartje, Lin, Xianming, Chkourko, Halina, Liang, Feng-Xia, van der Nagel, Roel, Hund, Thomas, Birchmeier, Walter, Mohler, Peter, van Veen, Toon A., van Rijen, Harold V., Delmar, Mario
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2012
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422082/
https://ncbi.nlm.nih.gov/pubmed/22764151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvs218
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