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Regulation of Insulin Signaling by the Phosphatidylinositol 3,4,5-Triphosphate Phosphatase SKIP through the Scaffolding Function of Pak1

Skeletal muscle and kidney-enriched inositol polyphosphate phosphatase (SKIP) has previously been implicated in the regulation of insulin signaling in skeletal muscle. Here, we present the first report of the mechanisms by which SKIP specifically suppresses insulin signaling and the subsequent gluco...

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Autors principals: Ijuin, Takeshi, Takenawa, Tadaomi
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422014/
https://ncbi.nlm.nih.gov/pubmed/22751929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00636-12
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