The Presence of an FKS Mutation Rather than MIC Is an Independent Risk Factor for Failure of Echinocandin Therapy among Patients with Invasive Candidiasis Due to Candida glabrata

Echinocandins are frontline agents against invasive candidiasis (IC), but predictors for echinocandin therapeutic failure have not been well defined. Mutations in Candida FKS genes, which encode the enzyme targeted by echinocandins, result in elevated MICs and have been linked to therapeutic failure...

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Detalhes bibliográficos
Main Authors: Shields, Ryan K., Nguyen, M. Hong, Press, Ellen G., Kwa, Andrea L., Cheng, Shaoji, Du, Chen, Clancy, Cornelius J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Susceptibility
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421882/
https://ncbi.nlm.nih.gov/pubmed/22751546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00027-12
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