Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening

Whole-cell screening of Mycobacterium tuberculosis (Mtb) remains a mainstay of drug discovery but subsequent target elucidation often proves difficult. Conditional mutants that under-express essential genes have been used to identify compounds with known mechanism of action by target-based whole-cel...

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Detalhes bibliográficos
Main Authors: Abrahams, Garth L., Kumar, Anuradha, Savvi, Suzana, Hung, Alvin W., Wen, Shijun, Abell, Chris, Barry, Clifton E., Sherman, David R., Boshoff, Helena I.M., Mizrahi, Valerie
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421836/
https://ncbi.nlm.nih.gov/pubmed/22840772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.05.020
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